Infertility can be a stressful situation and finding the optimal aid can often be the defining factor to starting a family. At Create Fertility Centre, our goal is to find the best fertility options for you. Although state-of-the-art technology is at our disposal, sometimes the solution can be much simpler. As such, we offer a wide variety of services and treatments that are catered to your needs.

Assited Hatching

After an egg is fertilized in the laboratory, the cells begin to divide. During these initial stages of development, the embryo is contained in a layer of proteins knowns as the zona pellicuda.

In order to successfully implant into the uterine lining, an embryo has to hatch out of the zona pellucida and attach to the walls of the uterus. Assisted hatching is a newer lab technique that was developed when fertility experts observed that embryos with a thin zona pellucida had a higher rate of implantation during IVF. With assisted hatching, an embryologist uses micromanipulation under a microscope to create a small hole in the zona pellucida. This happens on the third day of embryo development when the embryos contain an average of six to eight cells. The embryos are stabilized by a holding pipette. On the opposite side, a srnall laser creates a small defect in the Lona pellucid," The embryos are then returned to the incubator for further development.


Medical ultrasound (also known as diagnostic sonography or ultrasonography) is a diagnostic imaging technique based on the application of ultrasound.

It is used to create an Image of internal body structures. The practice of examining pregnant women using ultrasound is called obstetric ultrasound, and was an early development and application of clinical ultrasonography. Ultrasound are sound waves with frequencies which are higher than those audible to humans (>20,000 Hz). Ultrasonic images, also known as sonograms, are made by sending pulses of ultrasound into tissue using a probe. The ultrasound pulses echo off tissues with different reflection properties and are recorded and displayed as an image. It is a noninvasive test and do not use ionizing radiations.


Pre-implantation genetic diagnosis (PGD or PAD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization.

PGO is considered in a similar fashion to prenatal diagnosis. When used to screen for a specific genetic disease, Its maln advantage is that it avoids selective abortion, as the method makes it highly likely that the baby will be free of the disease under consideration. PGD thus is an adjunct to assisted reproductive technology, and requires in vitro fertilization (IVF) to obtain oocytes or embryos for evaluation. Embryos are generally obtained through blastomere or blastocyst biopsy. The latter technique has proved to be less deleterious for the embryo, therefore it is advisable to perform the biopsy around day 5 or 6 of development.


NIPT is a prenatal screening, which looks at DNA from your baby's placenta in a sample of your blood to identify whether you're at increased risk of giving birth to a child with a genetic disorder.

A screening like NIPT cannot, however, determine for sure whether your baby actually has a chromosomal disorder, only the likelihood of having that condition. The results of an NIPT screening can help you and your doctor next steps. Including whether to have a diagnostic test like chorionic villus sampling(CVS) or amniocentesis("amnio"). These genetic tests analyze a baby's own generic material, collected from the amniotic fluid or placenta, to tell with 100 percent certainty whether a baby has a chromosome abnormally. However they are invasive, which they slightly increase the chance of miscarriage.

Stem cell Therapy

Stem cells are a population of undifferentiated cells that originated from embryonic and fetal stages of development.

They are considered as potential alternative novel therapeutic agents for patients suffering from infertility due to their unlimited source and high differentiation potency. There are several studies that have shown that different types of stem ells (mesenchymal. embryonic, endometrial and ovarian stem cells) that can be differentiated into both spermatozoa and oocytes in vitro, providing their potential use in management and cure of infertility issues. Autologous stem cells infused intra-testicular under short protocol. Result of this study will help in changing the perspective of fertility potential in azoospermia patients. Other fields include erectile dysfunction, refractory endumetrium and premature ovarian failure. This has led to endometrial regeneration as well as successful implantation.


The ERA Endometrial Receptivity Analysis Is a personalized genetic test to diagnose the state of endometrIal receptivity In the window of implantation.

An endometrium is receptive when it Is ready for the embryo implantation. This occurs around days 19-21 in each menstrual cycle of a fertile woman. This period of receptivity is what we call the window of implantation.

The lack of synchronization between the embryo ready to be implanted and endometrial receptivity is one of the causes of recurring Implantation failure. This Is why it is imperative to assess the endometrium in order to determine the optimal day for embryo transfer.

USG/3D Color Doppler

Ultrasound imaging, also called ultrasound scanning or sonography, involves the use of a small transducer (probe) and ultrasound gel to expose the body to high frequency sound waves.

Ultrasound Is safe and painless, and produces pictures of the inside of the body using sound waves. Ultrasound examinations do not use ionizing radiation (as used in x-ray). Endometrial receptivity plays a crucial role in implantation of embryo and evaluation of endometrial receptivity is a challenge in clinical practice. Endometrial scoring Is a simple, noninvasive and authentic score to predict uterine environment and thereby outcome in COS-IUI/IVF cycles. Various parameters like endometrial thickness. Layering, Myometrial echogenecity, Doppler flow. Uterine artery, endometrial blood flow and Gray scale myometrial blood flow are measured.


Super ovulation is a term used to describe the drug-induced Production of multiple eggs for use in assisted reproductive technologies such as in vitro fertilization (IVF).

Normally, a woman ovulates Just one egg per cycle. With the use of fertility drugs, she may be able to produce several eggs, which can then be retrieved from the ovaries prior to ovulation. During ovulation induction, the goal is for the ovaries to mature only one or two eggs. With super ovulation, more than two eggs are desired. Super ovulation is also used during IUI treatment. However, due to the risks of a multiple pregnancies, IUI treatment typically involves ovulation induction. Risks of super ovulation include ovarian hyper stimulation syndrome, ovarian torsion, and multiple (twins, triples, etc.) pregnancy. There are also Potential risks and side enacts related to what kind A treatment is being used (IVF or IUI), as well as risks to the fertility drugs chosen.

Embryo Reduction

When a high order multiple pregnancy (three or more fetuses present in the womb at the same time) is 'selectively reduced' to twin or single pregnancy by injecting a drug, the procedure is called 'selective embryo reduction'.

It is a procedure whereby one or more fetuses are aborted so as to improve the outcome of the remaining fetuses. As the number of fetuses increase, the risks of preterm (early) delivery Aso increase. The average length of Pregnancy for a singleton is 40 weeks whereas for twins it is 36 weeks. This reduces dramatically to 32 to 33 weeks for triplets and 28 to 29 weeks for quadruplets. Embryo reduction is done by Passing a needle through the mother's tummy under local anesthesia and injecting a medicine into the fetus to be reduced. It is done under continuous ultrasound guidance.


Cryopreservation is based on the ability of certain small molecules to enter cells and prevent dehydration and formation of intracellular ice crystals, which can cause cell death and destruction of cell organelles during the freezing process.

Two common cryoprotective agents are dimethyl sulfoxide (DMS0) and glycerol. Glycerol is used primarily for cryoprotection of red blood cells, and DMS0 is used for protection of most other cells and tissues. A sugar called trehalose, which occurs in organisms capable of surviving extreme dehydration, is used for freeze-drying rnethods of cryopreservation. Trehalose stabilizes cell membranes, and it is particularly useful for the preservation of sperm, stem cells, and blood cells.

Follicular Monitoring

Follicular monitoring or follicular study is a vital component of In-Vitro Fertilization (IVF) assessment and timing. It basically employs a single technique for assessing ovarian follicles at regular intervals and documenting the pathway to ovulation.

Transvaginal ultrasound is preferred and usually mandatory modality for monitoring follicles. Ultrasound monitoring may begin on day 3 of the cycle, to assess a baseline size, as well as exclude if any cyst remains from previous hyper stimulation or otherwise. It is important to count the number of existing follicles, document two/three dimensions of each follicles. As the study progresses on day 7, we should start guessing the ovulatory dominant follicle i.e. dominant follicle which is destined to ovulate. Basically, there are three varieties of eligible follicles :

1. Atretic dominating follicle

2. Ovulatory domi4 follicle

3. Anovulatory-luteiniiing dominating follicle

Once the follicle reaches a size of 16-18 mm, a daily monitoring of follicle is recommended. Most of the IVF studies are conducted after induction of ovaries with help of ovulation inducing agents like Clomiphene Citrate/Letrozole/Gonadotropins. In such induced cycle, primary determinants of success are:

1. Ovarian volume

2. Antral follicle number

3. Ovarian stromal blood flow

Egg, sperm, and embryo donation

During the process of egg donation the eggs from the ovaries of a woman with normally functioning ovaries are retrieved.

These donated eggs are then fertilized in a laboratory setting (in vitro fertilization) with sperm from the egg recipient’s partner. The resulting embryos are then transferred to the uterus of the woman desiring a baby.


A sonohysterogram is an ultrasound procedure used to better visualize the inside of your uterus.

Most often it is used to view abnormalities of the uterine cavity that could interfere with pregnancy. It involves instilling a small amount of saline into the uterus and looking with transvaginal ultrasound.

Female fertility diagnostic services

Female fertility diagnostic services include blood testing, ultrasound, sonohysterogram, hysterosalpingogram, office hysteroscopy, laparoscopy, and in-hospital hysteroscopy.

It also includes basic fertility treatment, such as natural cycle monitoring, ovulation induction, and intrauterine insemination.

Male fertility diagnostic services

Male fertility diagnostic services includes following things.

Male fertility diagnostic services include blood testing; semen testing; routine semen-analysis and computer-assisted semen-analysis; anti-sperm antibody testing; sperm function tests; sperm DNA fragmentation assay; fluorescence in situ hybridization; fertility preservation and sperm banking; and electro-ejaculation.

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